PD-1 Blockade–induced Inflammatory Arthritis

Inflammatory cytokines compromise programmed cell death‐1 (PD‐1)‐mediated T cell suppression in inflammatory arthritis through up‐regulation of soluble PD‐1

The programmed cell death 1 (PD-1) receptor plays a major role in regulating T cell activation. Our aim was to determine how inflammation influences PD-1-mediated T cell suppression. Flow cytometry analysis of rheumatoid arthritis (RA) and psoriatic arthritis (PsA) synovial fluid (SF) mononuclear cells showed an increase in the percentage of PD-1+ cells within the CD4+ and CD8+ T cell compartme...

Subacute Inflammatory Arthritis Following Intravascular Coagulation Syndrome

Un nourisson de six mois a ete hospitalise dans le .,ervice de pediatrie du C.H.U. de Logmandolhe-Adham pour: deshydratation, etat septique, acidose metabolique, troubles circulatoires des membres avec gangrene de la main droite.  Le syndrome de la coagulation intra-vasculaire disse­minee (CID) a ete rapidernent confirme par l'etude de la erase sanguine. Soumis a un traitement par: solutes 6le...

Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade

Immune checkpoint blockades, such as inhibitors against programmed death 1 (PD-1) and its ligand (PD-L1), have received extensive attention in the past decade because of their dramatic clinical outcomes in advanced malignancies. However, both primary and acquired resistance becomes one of the major obstacles, which greatly limits the long-lasting effects and wide application of PD-1/PD-L1 block...

Critically Dependent on LFA-1 Manifestations of Inflammatory Arthritis Are

Trauma and Inflammatory Arthritis

Dr. Dafna D. Gladman graduated from the University of Toronto in 1971. She did post-graduate training in internal medicine from 1972 to 1975 and in rheumatology from 1975 to 1977 at the University of Toronto. She was granted her fellowship in internal medicine and in rheumatology in 1976. She joined the the University of Toronto faculty in 1977 and holds the rank of Professor of Medicine in the...